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DNA NanoTechnology

DNA NanoTechnology

One of the new fields in nanotechnology is using nucleic acids (the “building blocks” of DNA) to make various nanometer scale structures. Properly constructed structures of nucleic acids can be used to create things ranging from crystal lattices to molecular machines and DNA computers.

Chengde Mao – Mao, Chengde (December 2004). “The Emergence of Complexity: Lessons from DNA”. PLoS Biology 2 (12): 2036-2038. ISSN 1544-9173. doi:10.1371/journal.pbio.0020431
Antony-22 – Own work
DX array. Each bar in the schematic (left) represents a helical domain with matching “sticky ends”. They assemble into a two-dimensional array as shown in the AFM image (right–150 nm field of view). This is a simple example of how DNA can be used to make two-dimensional structures. More complex constructs are also possible and the results can be examined using Atomic Force Microscopy.

In addition to two dimensional lattices, three dimensional structures can be made using DNA. One example is simple polyhedra with each edge being a strand of DNA.

Active devices can also be constructed of DNA–DNA machines. One example is DNA tweezers (or perhaps pliers would be a better term, but “tweezers” is what is used), where two strands of DNA are connected from their midpoints with another strand. The tweezers can be opened or closed by exposure to yet other strands which link between the “jaws” of the tweezers pulling them closed or breaking that connection allowing them to open again.

Multiplexed DNA detection with DNA tweezers in a one-pot reaction

Asymmetric patterning drives the folding of a tripodal DNA nanotweezer

Advanced Surface Microscopy has experience in imaging and measuring DNA in the Atomic Force Microscope and can bring this experience to developers of DNA Nanotechnology and other related fields.